Aplastic Anemia and MDS Awareness Week is December 1-7.
Aplastic anemia is a disease of the bone marrow. It happens when the bone marrow stops making enough red blood cells, white blood cells and platelets for the body. Any blood cells the marrow does make are normal, but there are not enough of them. Aplastic anemia can be moderate, severe or very severe. People with severe or very severe aplastic anemia are at risk for life-threatening infections or bleeding. Although aplastic anemia can appear at any age, it is diagnosed more often in children and young adults. Several well-known figures from history had aplastic anemia, including chemist and Nobel Prize recipient Madame Curie and former First Lady Eleanor Roosevelt.
Aplastic anemia is caused by destruction of the blood-forming stem cells in your bone marrow. These stem cells normally develop into three types of blood cells: red blood cells, white blood cells and platelets. Most research suggests that stem cell destruction occurs because the body’s immune system attacks its own cells by mistake. Normally, the immune system attacks only foreign substances. When your immune system attacks your own body, you are said to have an autoimmune disease. Aplastic anemia is generally thought to be an autoimmune disease. Other autoimmune diseases include rheumatoid arthritis and lupus.
Aplastic anemia can be acquired or hereditary.
- Acquired aplastic anemia can begin any time in life. About 75 out of 100 cases of acquired aplastic anemia are idiopathic. This means they have no known cause.
- Hereditary aplastic anemia is passed down through the genes from parent to child. It is usually diagnosed in childhood and is much less common than acquired aplastic anemia. People who develop hereditary aplastic anemia usually have other genetic or developmental abnormalities.
About 25 out of 100 cases of acquired aplastic anemia can be linked to one of several causes. These include:
- Toxins, such as pesticides, arsenic, and benzene
- Radiation and chemotherapy used to treat cancer
- Treatments for other autoimmune diseases, such as lupus and rheumatoid arthritis
- Pregnancy – sometimes, this aplastic anemia improves on its own after the woman gives birth
- The symptoms of aplastic anemia are caused by low blood cell counts. The symptoms depend on which type of blood cell is affected.
- Low red blood cell count
- A low red blood cell count is called anemia. Red blood cells carry oxygen from your lungs to the rest of your body. A low red blood cell count causes fatigue and tiredness.
- Low white blood cell count
- A low white blood cell count is called neutropenia. White blood cells fight infections in the body by attacking and killing bacteria and viruses. A low white blood cell count can increase the risk for infections.
- Low platelet count
- A low platelet count is called thrombocytopenia. Platelets help blood to clot and stop bleeding. A low platelet count can lead to bleeding problems and cause you to bruise easily.
